Functional Food Peptides for Appetite Control

The release of so called anti-diabetic, anti-obesity gut hormone cholecystokinin (CCK) from I-cells of the small intestine is stimulated by some food peptides, which in turn suppresses appetite by producing a feeling of satiety. This study investigated appetite-suppressive and CCK-releasing activity in peptides derived from proteins after enzymatic hydrolysis. The stimulatory activity was examined in a murine enteroendocrine cell (EEC) line STC-1 followed by investigating active peptides for appetite-suppression in rats. Among peptones prepared from meat and legumes, pork peptides suppressed appetite correspondingly with binding to rat small intestinal brush-border membrane and by stimulating CCK secretion from the EECs. Peptides in country bean (Dolichos lablab) had the highest stimulation in CCK-secretion. The active peptides are originated from ‘dolicholin’–a newly identified protein in country bean. Despite low peptide content, brewer’s yeast extract with ~14 kDa peptides showed very high CCK-releasing properties. These findings laid ground for elucidation of active peptide structure and understanding molecular mechanism for development of functional food for human consumption.

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Характеристики товара

ISBN9783659307799
Автор на обложкеMd. Kaosar Niaz Bin Sufian,Hiroshi Hara and Tohru Hira
Вес501
Высота упаковки1
Глубина упаковки1
Год выпуска2012
ИздательствоLAP Lambert Academic Publishing
Количество страниц132
Ширина упаковки1
Язык изданияАнглийский

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